Heme Oxygenase as a Shock Protein.
نویسندگان
چکیده
منابع مشابه
Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.
Catalytic activity of heme oxygenase (heme, hydrogen-donor:oxygen oxidoreductase, EC 1.14.99.3) isozymes, HO-1 and HO-2, permits production of physiologic isomers of bile pigments. In turn, bile pigments biliverdin and bilirubin are effective antioxidants in biological systems. In the rat brain we have identified only the HO-1 isozyme of heme oxygenase as a heat shock protein and defined hypert...
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Heme oxygenase (HO), the rate limiting enzyme in the breakdown of heme into carbon monoxide (CO), iron and bilirubin, has recently received overwhelming research attention. To date three mammalian HO isozymes have been identified, and the only inducible form is HO-1 while HO-2 and HO-3 are constitutively expressed. Advances in unveiling signal transduction network indicate that a battery of red...
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hydrogen donor: oxygen oxidoreductase (í µí»¼-methene hydroxylating, decycliz-ing)) catalyzes the rate limiting the step in the oxidative catabolism of heme to generate biliverdin-IXí µí»¼, which is subsequently converted to bilirubin-IXí µí»¼ by cytosolic NAD(P)H-dependent biliverdin reductase [1]. This reaction, which requires molecular oxygen as well as electrons from NADPH-dependent cytochr...
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This study characterizes microsomal heme oxygenase, a previously undescribed enzyme which catalyzes the oxidation of heme at the cr-methene bridge to form biliverdin. This step is then coupled with soluble NADPH-dependent biliverdin reductase to form bilirubin; microsomal heme oxygenase is rate-limiting in this pathway. By all analytical criteria, the product of this reaction is bilirubin. Most...
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Overproduction of reactive oxygen species under pathophysiological conditions, including dyslipidemia, hypertension, diabetes, and smoking, is integral in the development of cardiovascular diseases (CVD). The reactive oxygen species released from all types of vascular cells regulate various signaling pathways that mediate not only vascular inflammation in atherogenesis but also antioxidative an...
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ژورنال
عنوان ژورنال: Eisei kagaku
سال: 1995
ISSN: 0013-273X
DOI: 10.1248/jhs1956.41.14